Clodronate Liposome And The Importance Of Its Discovery

By Roxanne Cruz


Medical science, being one of the most fascinating field in the industry has found different solutions to different problems over time. Before, yellow fever for example killed thousands of residents in different areas. But because of the discoveries of the assiduous medical scientists, yellow fever vaccine was invented. Clodronate liposome is one of those outstanding discoveries that will play a great role in the field of medicine.

Clodronic acid or clodronic sodium, or more commonly known as clodronate liposome is the first generation of non nitrogen bisphosphonate. It is a drug and approved scientifically to treat and prevent the cases of osteoporosis. This happened when women already reach the stage of post menopausal time. In experimental science, it is used to decrease macrophages.

Macrophages are white blood cells found inside the tissue. They produced through the division of white blood cells that was formed in the spleen and bone marrow or monocytes. They eat foreign and cell particles after its formation. Macrophage is said to be the core of the immune system.

In cell biology, liposomes are the tiny bubble which are composed of fatty sacs with liquid inside. These are used in both research and experiment in cell biology. It is filled with drugs that are used to cure cancer and different diseases. It is filled with liquid and phospholipids.

Science discovered clodronate liposome acts for the suppression of the macrophage. Indeed immune system defends the invasion of infectious viruses and bacteria. Through immune response, it will attack the invaders that will cause diseases to the organ or body. However, the immune system can be the source of disease in the body.

In most circumstances, the immune system helps the body cope up diseases like fever and colds. However, when it is damaged, it will attack all the cells including the healthy ones. With a stroke of misfortune, several grave disorders will take place.

As mentioned earlier, immune response protects the body from viral invasion. However, several damages will lead to grave autoimmune medical conditions caused by transplant rejection. This transplant rejection is one of the effects of the response. As a new organ in places on the transplant patient, cells will incite the system to attack the organ cells that will lead to rejection.

Because of the autoimmune disorders that could actually happen, here comes the discovery of the mighty liposome. This is composed of bisphosphonate and will deplete macrophages. After it was transported, macrophage will detect that it is alien. In result, it will engulf it through the thing so called phagocytosis.

Clodronate liposome is said to treat cancer through the increase absorption of plasma. It also improves the effects of anti tumor drugs to treat cancer. Even if this discovery is really fascinating, consult the medical doctor first before deciding to take this drug. This is for your safety, after all.




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